Sipho Seroto began school at age 6 at Ditshaba Primary School in 1995 and matriculated at Panorama Combined School in Newcastle, KwaZulu-Natal in the year 2008. After completing matric in 2008, he came to Johannesburg in 2009 and started to work as a part-time television extra for some local soapies.
In 2010, he completed a TV presenting course at Media Concepts and was awarded a certificate. In 2012, he worked as a canvasser for new accounts at Edgars. In 2016, Sipho was featured in a SHOWMAX TV commercial and also began to work at William Kentridge's art workshops as a stage performer and actor on a part-time basis.